Abstract: Thyroid disease is one of the major diseases of the endocrine system. The diagnosis of this disease involves many disciplines. In order to improve the quality of teaching in thyroid disease, department of endocrinology, nuclear medicine, cardiology, general surgery and other relevant departments should cooperate, and diversified teaching methods should be flexible applied during the course of teaching. Multi-disciplinary cooperation and diversified teaching methods can not only improve the students' interesting and enthusiasm in learning thyroid disease, but also develop the ability of their learning, practicing and innovation in clinic.