Objective To evaluate the genotype and age distribution of human genotype papilloma virus (HPV) infection in 13452 cases. Methods The 21different genotypes including 14 high-risk genotypes and 7 low-risk genotypes of HPV in 13452 cases were detected by flow through tybridization. Results The total positive rate of HPV infection was 36.98%. All 21different genotypes were found. The most common high-risk genotype and low-risk genotype was HPV16 and HPV53, respectively. The multiple infection rate was 24.08% and two co-infections were the most common situation. Conclusion The 3 most common high-risk genotypes of HPV infection are HPV16, 58, 52,and the 2 most common low-risk are HPV53 and cp8304. The infection peak age is 19 to 29 years old and ≥60 years old. Two types co-infection are the most common multiple HPV infection.
WEI Bao-jun
,
LI Xue-xiang
,
QI Jun
. Detection of Human Genotype Papilloma Virus Infection in 13452 Cases[J]. Labeled Immunoassays and Clinical Medicine, 2013
, 20(3)
: 169
-171
.
DOI: 10.11748/bjmy.issn.1006-1703.2013.03.015
[1] Walboomers J M, Jacobs M V, Mans M M,et al. Human papillomvirus is a necessary cause of invasive cervical cancer worldwide[J].J Pathol,1999, 189(1): 12-19.
[2]McLachlin C M. Human papillomavirus in cervical neoplasia. Role, risk factors, and implications [J].Clin Lab Med, 2000,20(2):257-270.
[3]Muoz N, Bosch F X, de Sanjosé S,et al.Epidemiologic classification of human papillomavirus types associated with cervical cancer[J].N Engl J Med,2003,348 (6): 518-527.
[4]Li N, Franceschi S, Howell-Jones R, et al. Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication[J]. Int J Cancer, 2011,128(4):927-935.
[5]Muoz N, Bosch F X, Castellsagué X, et al. Against which human papillomavirus types shall we vaccinate and screen? The international perspective [J]. Int J Cancer, 2004,111(2):278-285.
[6]Usubütün A, Alemany L, Küükali T, et al.Human papillomavirus types in invasive cervical cancer specimens from Turkey[J]. Int J Gynecol Pathol, 2009, 28 (6): 541- 548.
[7]Dai M, Bao Y P, Li N, et al. Human papillomavirus infection in Shanxi Province, People’s Republic of China: a population-based study[J].Br J Cancer, 2006,95(1):96-101.
[8]Li Y, Wang Y, Jia C, et al. Detection of human papillomavirus genotypes with liquid bead microarray in cervical lesions of northern Chinese patients[J].Cancer Genet Cytogenet,2008,182(1):12-17.
[9]Bao Y P,Li N,Smith J S,et al. Human papillomavirus type distribution in the cervix of Chinese women: a meta-analysis [J].Int J STD AIDS, 2008,19(2): 106- 111.
[10]Chan P K, Li W H, Chan M Y, et al. High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions[J].J Med Virol,1999,59(2):232-238.
[11]陶萍萍,卞美璐,欧华,等.导流杂交基因芯片技术在人乳头瘤病毒检测中应用的研究[J].中华妇产科学杂志,2006,41(1):43-47.
[12]杨英捷,赵健,李雪倩,等.2285例女性下生殖道人乳头瘤病毒感染筛查结果分析[J].中国实用妇科与产科杂志,2006,22(6):444-445.
[13]Castle P E, Schiffman M, Herrero R, et al. A prospective study of age trends in cervical human papillomavirus acquisition and persistence in Guanacaste, Costa Rica [J]. J Infect Dis, 2005,191 (11): 1808-1816.
[14]靳琼,沈铿,李辉,等.西藏自治区妇女宫颈人乳头状瘤病毒感染现状调查及相关因素分析[J].中华妇产科学杂志,2009,44(12):898-902.
[15]梁德光,何三恒,蓝柯.人乳头瘤病毒及其致瘤机制的研究进展[J].生命科学,2008,20(6):843-848.
