Objective To explore the clinical significance of anti-nuclear antibody (ANA) detection in the diagnosis of systemic lupus erythematosus (SLE) patients. Methods The serum ANA and anti-nuclear antibody spectrum (ANAs) of 12 kinds of antibodies in 106 SLE patients and 30 healthy control group were detected by indirect immunofluorescence assay (IIF) and western blot detection. Results The results showed that the positive rate of ANA was 86.8% in SLE patients, and positive rates of ANAs in anti-ds-DNA, anti-Scl-70、anti-Jo-1、anti-nRNP, anti-Sm, anti-SS-A, anti-SS-B, anti-Ro-52, anti- CENP-B, anti-AnuA, anti-AHA and the ribosomal P-protien were 28.3%, 0.9%, 0.9%, 35.9%, 17.0%, 39.6%, 18.9%, 41.5%, 9.4%, 29.3%, 31.1% and 9.4%, respectively. Conclusion The combined detection of ANA and ANAs could improve the sensitivity and have important significance in the diagnosis and treatment of SLE.
JIANG Su-ying
,
LU Yong-fang
,
XIE Dan-ping
,
ZHANG Jin-zhen
. Clinical Significance of Anti-nuclear Antibodies Detection in the Diagnosis ofSystemic Lupus Erythematosus[J]. Labeled Immunoassays and Clinical Medicine, 2013
, 20(3)
: 161
-163
.
DOI: 10.11748/bjmy.issn.1006-1703.2013.03.013
[1] 王兰兰. 临床免疫学和免疫学检验[M].第三版:北京:人民卫生出版社,2003:190.
[2] 许珂,李小峰,胡学芳,等. 系统性红斑狼疮血清抗核小体抗体水平及意义的探讨[J].中华风湿病学杂志,2005,9:72-76.
[3] 唐福林.抗核小体抗体的临床意义[J]. 中华风湿病学杂志, 2003,7(8):457.
