Objective To explore the changes of CD4+CD25+ regulatory T cells in peripheral blood of neonatal patients with hypoxic-ischemic encephalopathy(HIE), and its significance in the process of HIE. Methods The levels of CD4+CD25+Tcells and changes of the foxp3 expression in 92 patients with HIE and 31health children were detected by flow cytometry. Results The levels of CD4+ CD25 + T cells in the peripheral blood of moderate and severe HIE neonates were significantly lower than that of controls(P＜0.05). The foxp3 expression in CD4+CD25+ T cells in peripheral blood of moderate and severe HIE neonatal were significantly lower than that the controls(P＜0.05). Conclusion The CD4+CD25+ foxp3+ T cell in moderate and severe HIE children are significantly reduced, and these regulatory T cells may be involved in the pathological process of HIE.
SUN Lin
,
SONG Ji-cheng
,
ZHOU Xu-hua
. The Changes and Significance of CD4+ CD25+ Regulatory T Cell inPeripheral Blood of Neonates with Hypoxic-ischemic Encephalopathy[J]. Labeled Immunoassays and Clinical Medicine, 2013
, 20(3)
: 135
-136
.
DOI: 10.11748/bjmy.issn.1006-1703.2013.03.003
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