Objective To explore the effect of Peristrophe Roxburghiana on the expression of TGF-β1 and VEGF in hepatic fibrosis rats induced by dimethylnitrosamine . Methods The model of hepatic fibrosis rats induced by dimethylnitrosamine was intervened with different concentrations of Peristrophe Roxburghiana. The conventional flaking of liver and HE were used to observe histopathological staining change. The expressions of TGF-β1and VEGF in hepatic tissue were detected by immunohistochemistry. Results The expressions of TGF-β1and VEGF in hepatic fibrosis rats with high and middle dose of Peristrophe Roxburghiana were significantly lower than that of controls (P＜0.05). Conclusion Peristrophe Roxburghiana may have a good curative effect of anti hepatic fibrosis. Its therapeutic mechanism may mainly be related to adjustment of metabolism of extracelluar matrix by decreasing TGF-β1and VEGF expression.
HUANG Jun-min
,
LI Zhi-chao
,
LI Hong-li
,
CAO Qing-sheng
,
ZHANG Xue-ying
. The Effect of Peristrophe Roxburghiana on the Expressions of TGF-β1 andVEGF in Hepatic Tissue of Hepatic Fibrosis Rats[J]. Labeled Immunoassays and Clinical Medicine, 2013
, 20(2)
: 96
-98
.
DOI: 10.11748/bjmy.issn.1006-1703.2013.02.012
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