Objective To explore the clinical diagnostic values of combined detection of serum p53 Abs, VEGF and AFP in patients with HCC. Methods 44 patients with HCC, 46 patients with liver cirrhosis and 50 healthy controls were involved in this study. The serum p53 Abs and VEGF levels were examined for by ELISA and the serum AFP levels were detected by MEIA. Results The serum levels of VEGF and p53 Abs in HCC patients were significantly higher than that in cirrhotic patients and control group (P＜ 0.05). The positive rate of VEGF and p53 Abs (61.36%, 22.73%) in HCC patients were also higher than that in liver cirrhosis (8.70%,2.17%) and healthy controls (P＜ 0.05). The serum VEGF expression was related with the size of HCC, PVI, while was not related with AFP levels and the infection of HBV. The p53 Abs expression was independent of the size of HCC, PVI, and AFP levels and the infection of HBV. The sensitivity of combined measurement of VEGF or p53 Abs and AFP was better than that AFP alone. There was no correlation between either p53 Abs or VEGF and AFP levels. However, the positive rate of VEGF and p53 Abs were 46.67% and 33.33% respectively in AFP negative patients with HCC. Conclusion The serum VEGF and p53 Abs may be considered as additional tumor markers to increase the diagnostic values of AFP in patients with HCC.
ZHANG Hua
,
LI Yong-xing
,
MAO Shun-lu
,
LE Yan
,
XIANG Ming-jie
. Clinical Significance of Detection of Serum VEGF, p53 Antibodiesand AFP in Patients with HCC[J]. Labeled Immunoassays and Clinical Medicine, 2013
, 20(2)
: 71
-73
.
DOI: 10.11748/bjmy.issn.1006-1703.2013.02.003
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