Objective To explore the changes of serum 8-iso-PGF2α,superoxide dismutase (SOD) and malondialdehyde(MDA) levels in patients with essential hypertension.Methods The content of 8-iso-PGF2α, SOD and MDA levels in 193 cases of essential hypertension and 52 controls were detected by using ELESA, xanthine oxidase and thiobarbituric acid method. Results The serum 8-iso-PGF2α levels in patients were obviously higher than those in controls (P＜0.05), the SOD levels were significantly lower than those in controls (P＜0.01) and the MDA levels were significantly higher than those in controls (P＜0.01). When the blood pressure increased, the content of SOD was decreased, and there was a significantly negative correlation (r=－0.74). But to the 8-iso-PGF2α and MDA, when the blood pressure increased the content of them was increased,There was a significantly positive correlation between the blood pressure with 8-iso-PGF2α and MDA levels respectively (r=0.62, r=0.81). Conclusion The levels of serum 8-iso-PGF2α, SOD and MDA are closely correlated to the severity of hypertension, and they may be used for evaluation of patients with hypertension.
LIU Ning
,
SUN An-ping
,
WANG Jin-song
,
LIU Jing
,
JIANG Chu-tao
,
Xiao Jun
,
LUO Rong
,
JIN Wen-ping
,
YU Xin- zhi
,
WANG Jun-jun
,
ZHOU Hong
. Clinical Significance of Changes of Serum 8-iso-PGF2α, SOD andMDA Levels in Patients with Hypertension[J]. Labeled Immunoassays and Clinical Medicine, 2013
, 20(1)
: 7
-10
.
DOI: 10.11748/bjmy.issn.1006-1703.2013.01.003
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