Objective To investigate the diagnostic value of alone or combined detection of Soluble Lox-1(sLox-1) and High-sensitivity Troponin I (hs-TnI) by using ROC curve in acute coronary syndrome (ACS). Methods 119 patients with ACS had been confirmed by coronary angiography were divided into ACS group (78 patients) and stable angina group (41patients), and 41cases of NCHD patients had also been confirmed by coronary angiography. The serum levels of sLox-1, hs-TnI, Myo, TnI and CKMB in these patients were measured by ELISA, and the Logistic regression model and the area under curve (AUC) of ROC curves were used to evaluate the diagnostic value for ACS. Results The AUC of the ROC curve biomarkers alone and the combination of “TnI+Myo+CKMB”. sLox-1for sLox-1and hs-TnI was 0.934 and 0.918 respectively. The AUC of the “sLox-1+ hs-TnI” combination for ACS was 0.974. The diagnostic sensitivity and specificity was 95.1% and 96.2%, respectively, which was higher than that any of the and hs-TnI both have certain value for diagnosing ACS. Conclusion sLox-1plus hs-TnI combination plays a better role in diagnosing ACS than that either sLox-1and hs-TnI alone or the “TnI+Myo+CKMB” combination.
LI Dan
,
LIU Chun-lei
,
HE Jia-yan
,
BING Yan
,
GAO Jiao
,
CHEN Xing-ming
,
JING Hua
. Clinical Significance of Combined Detection of Soluble Lox-1 andHigh-sensitivity Troponin I and Evaluated by ROC Curve inDiagnosis of Acute Coronary Syndrome[J]. Labeled Immunoassays and Clinical Medicine, 2013
, 20(1)
: 1
-3
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DOI: 10.11748/bjmy.issn.1006-1703.2013.01.001
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