Abstracts:Objectives To investigate the clinical value of combination detection of serum Tg and CEA in benign and malignant thyroid tumors.Methods The serum Tg and CEA were measured with electrochemiluminesence immunoassay for 68 differentiated thyroid carcinoma before surgery and after thyroidectomy followed by 131I treatment. The serum Tg and CEA were also measured for 65 thyroid neoplasm patients, and 55 health subjects as the control separately. The levels of Tg and CEA were statistic analyzed with SPSS13.0 software.Result The level of serum CEA in DTC before surgery were significantly higher than benign thyroid tumors (P<0.05), however there were no significant difference of Tg between DTC and the benign thyroid tumors. The levels of Tg in DTC was significantly decreased after 131I treatment. The serum CEA and Tg in different stages of thyroid carcinoma were also significantly difference, the serum CEA and Tg in stage I and II of thyroid carcinoma is significant lower than those in stage III and IV (P<0.05). Conclusion The combination detection of serum CEA and Tg is a great value in evaluating the 131I treatment effect and predicting the prognosis of DTC. The examination of CEA is also an important auxiliary diagnostic method for advanced DTC patients.