Abstract: Objective To investigate the clinical application value of continuous renal replacement therapy (CRRT) in the treatment of patients with sepsis acute kidney injury (AKI). Methods 200 patients with septic acute kidney injury were randomly divided into observation group (100 patients treated with CRRT) and control group (100 patients treated with conventional drugs). The changes of clinical indexes in both groups were analyzed. Results The survival and mortality rate in observation group during 30 days treatment had obvious advantage compared with control group (P<0.05). As to the AKI staging in control group, there was no significantly difference in the NI and NII between survival and death patients (P>0.05), while in NIII, the survival patients were significantly lower than that of the death patients (P<0.01). The significant difference on AKI NI and AKI NIII in observation group were seen between survival and death patients (P<0.01). The incidence of complications rate in survival patients was much less than that of death patients in both two groups (P<0.01). There was no significantly difference in the treatment time interval of chronic obstructive pneumonia between survival and death patients in observation group (P>0.05). However, the time interval from entering ICU to carrying CRRT in survival patients was significantly shorter than that of death patients (P<0.01). Conclusion CRRT could effectively remove inflammatory factor in the treatment of patients with sepsis acute kidney injury, reduce the mortality and maintain the relative stability of internal environment. The early CRRT application might improve the 30-days survival rate of patients with sepsis acute kidney injury.