Abstract: 0bjective To explore the clinical significance of serum homocysteine (Hcy) in patients with osteoporosis. Methods 128 cases of osteoporosis patients and 72 healthy people as controls were involved in this study. The serum Hcy levels in patients and healthy controls were detected and the results were analyzed. Results The serum Hcy levels in patients with osteoporosis were significantly higher than that of healthy controls (P<0.05). Conclusion The detection of serum Hcy have an important clinical valve and could be used as an auxiliary index in the diagnosis of patients with osteoporosis.