Abstract: Objective To evaluate the clinical significances of combined detections of autoantibodies, immunoglobulin and complement in patients with systemic lupus erythematosus. Methods 54 SLE patients, 32 other autoimmune diseases patients and 30 healthy people were involved in the study. ANA was tested by indirect immunofluorescent method (IIF), ENA was tested by Western blot, the level of IgG, IgA, IgM, C3 and C4 were tested by turbidimetric method. Results The positive rates of ANA, anti-dsDNA, anti-Sm, AnuA, anti-U1-nRNP, ARPA and anti-Histone in SLE patients were 87.04%, 59.26%, 27.78%, 29.63%, 37.04%, 12.96% and 27.78% respectively. The positive rates of anti-dsDNA and AnuA in the SLE active group were significantly higher than the SLE inactive group (P<0.05). Immunoglobulin in the SLE active group was significantly higher than the normal control group. The C3 and C4 level was significantly lower than the normal control group (P<0.01). Conclusion The combined detection of autoantibodies, immunoglobulin and complement have great reference value for the clinical diagnosis and illness evaluation of SLE patients．