Abstract: Objective To evaluate the differential diagnostic value of serum CA724 on gastric cancer and gastric benign diseases. Methods Chinese medical databases (2011-2014) were searched to collect articles in Chinese which evaluated the diagnostic value of CA724 in patients with gastric cancer. The data were analyzed by using Meta-Disc1.4 software. Meta-analysis of the reported sensitivity and specificity of each study and summary receiver operating characteristic (SROC) curve were performed. Results A total of 9 researches involving 2048 patients were included. The pooled sensitivity and specificity were 42% (39%~45%) and 94% (92%~95%). The area under the SROC curve was 0.8769 (0.7256~1). Conclusion CA724 can be regarded as a valuable marker in the differential diagnosis of gastric cancer and gastric benign diseases.