Abstract: Objective To explore the correlation between obstructive sleep apnea hypoventilation syndrome (OSAHS) and hypersensitive C-reactive protein. Methods 40 cases of patients with obstructive sleep apnea hypoventilation syndrome 40 normal healthy controls were involved in this study. The hypersensitive C-reactive protein levels in patients and healthy controls were detected. Results The AHI times per hour in patients with OSAHS were significantly higher than that of healthy controls. The lowest oxygen saturation in patients was significantly lower than that of controls. The hypersensitive C-reactive protein levels in patients were significantly higher than control group (p < 0.05). Conclusion The hypersensitive C-reactive protein level could reflect severity of obstructive sleep apnea hypoventilation syndrome, and may be used as an index for auxiliary diagnosis and treatment of patients with OSAHS.