Abstract: Objective To explore the dynamic change of tissue vascular endothelial growth factor (VEGF) and plasma endothelin-1 expression in electrical burned rats. Methods Seventy-two rats were divided into two groups randomly. Eight rats were selected to be normally controlled and the others were established as electrical burned rat models. The immunohistochemical method was applied to detect the level of tissue VEGF expression at different time points such as 1 day，3 days，5days and 7 days after burn. ELISA was used to examine the plasma endothelin-1 concentration at different time points such as 2 hours，6 hours，12 hours and 24 hours after burn. Results Tissue VEGF expression at different time points in electrical burned group was higher than that in control group, and it reached the peak value at 7 days after burn. The plasma endothelin-1 level of burn rats was significant increased. It was significant higher than normal level after 2 hours and reached the peak value at 6 hours after the rates were burned. Then the plasma endothelin-1 expression declined gradually, and at 24 hours the endothelin-1 expression was still higher than that in the control group. Conclusion The expression of VEGF and endothelin-1 was significantly increase, which may involve in regulation of microvascular permeability.