Abstract: Objective To investigate the association of polymorphism of inhibin beta gene and outcomes of pregnant women in preeclampsia and neonatal perinatal. Methods 185 pregnant women with preeclampsia as subject group and 120 normal pregnant women as control group were involved in this study. The inhibin beta gene in patients and normal controls were detected by polymerase chain restriction fragment length polymorphism (PCR-RFLP) method. The genotype frequency and allele frequency were analyzed. Results The CC, CT and TT genotypes were detected in inhibin β gene rs505922 locus. There was statistical significance on genotype frequency and allele frequency between two groups (P < 0.05). The neonatal asphyxia and mortality rate in preeclampsia pregnant women with CT and CC genotypes were higher than that with TT genotype (P < 0.05). Conclusion The polymorphism of inhibin β-rs505922 are closely related with preeclampsia of pregnant women. The inhibin β-rs505922 may be the susceptible site of preeclampsia.