Abstract: Objectives To study the association of endocrine dehydroepiandrosterone sulfate (DHEAS) and total testosterone (TT) parameters with dyslipidemia in women with polycystic ovary syndrome (PCOS). Methods Two hundred and nineteen untreated women with PCOS were enrolled .The levels of serum DHEAS, TT and lipid profiles were measured and the results were analyzed statistically. Results The BMI, DHEAS, total cholesterol (CHOL), low-density lipoprotein (LDL-C) and apolipoprotein-B (ApoB) levels in the higher TT Group were significantly higher than that of the lower TT group (P < 0.05). The apolipoprotein-A (ApoA I) level was significantly higher in the higher DHEAS Group compared with the lower DHEAS group (P < 0.05). The TT level was positively correlated with the BMI, DHEAS, CHOL, LDL-C and ApoB levels, but inversely related to age（P<0.05）. The DHEAS level was positively correlated with the TT, HDL-C and ApoA I levels, but inversely related to ApoB level（P<0.05）. Conclusion The results suggest high DHEAS level was associated with better lipid profiles, whereas high TT level was associated with poor lipid profiles. It is important to make a distinction between adrenal and ovarian hyperandrogenism when evaluating dyslipidemia and coronary heart disease in PCOS.