Abstract：Objective To explore the expressions of chemokine receptor CXCR4 and CXCR7 in thyroid cancer and its clinicopathologic significance. Method 83 patients with thyroid cancer and 45 patients with thyroid adenoma were selected. The expressions of CXCR4 and CXCR7 were detected in all the selected cases samples by immunohistochemical SP technique. Results The positive expression rates of CXCR4 and CXCR7 in the thyroid cancer were higher than those in the thyroid adenoma (P＜0.05), in which the thyroid cancer with clinical stage Ⅲ~Ⅳwere higher than those of the clinical stage I~II (P＜0.05). The positive expression rate of CXCR7 in the thyroid cancer with lymph node metastasis was higher than that of the thyroid cancer without lymph node metastasis (P＜0.05), which of CXCR4 in the patients with thyroid cancer was independent of lymph node metastasis (P＞0.05). The expression of CXCR4 and CXCR7 were also independent of gender of the patients with thyroid cancer (P＞0.05). The positive expressions of CXCR7 in all the patients with thyroid cancer was positively correlated with CXCR4（r=0.49，P＜0.01), while poorly correlated was seen in thyroid adenoma（r=0.14，P=0.21）. Conclusion CXCR4 and CXCR7 are involved in the coordination of thyroid cancer progression. They could be used as prognostic indicators of thyroid cancer.