Objective To explore the regulatory effect of Huju Yigan capsule combined with adefovir dipivoxil on the immunity of patients with HBeAg positive chronic hepatitis B. Methods 64 cases of patients with HBeAg positive chronic hepatitis B were randomly divided into 2 groups, the control group of 30 cases were oral taken adefovir dipivoxil, 5 capsules each time for 3 times per day,  the treatment group of 34 cases were oral taken Huju Yigan capsule (5 capsules each time for 3 times per day) and adefovir dipivoxil (10mg/ days). The patients were treated for six months and follow-up for one year. Results Compared with the control group, the levels of ALT, AST and HBV-DNA levels in treatment group of HBeAg positive CHB patients were significantly reduced, and the clinical symptoms were obviously improved. The recovery rate of liver function, HBV DNA negative rate were significantly increased, the expression of IFN- γ and inhibition of IL-4 and TNF- α. were also significantly up-regulated in treatment group. Conclusion Huju Yigan capsule combined with adefovir dipivoxil in the treatment of chronic hepatitis B is safe and effective. It might improve liver function, regulate the body immune function and reduce the cytotoxicity of liver cells to reach better treatment effect for Patients with HBeAg Positive Chronic Hepatitis B.