Objective To explore the clinical value of detection of serum biochemical and biological markers levels in the patients with essential hypertension (EH) cerebral hemorrhage. Methods The serum levels of TC，TG，HDL-C，LDL-C and LP(a) or HCy，ATⅡand cTnⅠin 257 patients with single EH essential hypertension, in 207 patients with EH cerebral hemorrhage, and 61 controls were determined by biochemistry, enzyme immunoassay and immunoturbidimetry. Results The serum levels of TC，TG，LDL-C and LP(a) in 207 patients with EH cerebral hemorrhage were significantly higher than those in 257 patients with single EH [PTC<0.05, PTG<0.01, PLDL-C<0.05 and PLp(a)<0.05]. The serum levels of TC，TG，LDL-C and LP(a) in patients with EH cerebral hemorrhage and single EH were increased with blood pressure (E0，E1，E2 and E3). But the HDL-C level was low and decreased with blood pressure (E0，E1，E2 and E3). If FPG >6.1 mmol/L as standard, the glucose metabolic abnormal rate in 257 patients with single EH were 38.5%, but in 207 patients with EH cerebral hemorrhage were 52.9% (P<0.05). In biomarkers, the serum levels of HCy，ATⅡand cTnⅠin 207 patients with EH cerebral hemorrhage were significantly higher than those in 207 patients with single EH (P<0.05,<0.05 and <0.01 respectively), but were increased with blood pressure (E0，E1，E2 and E3)), and the HCy and cTnⅠ were significantly increased. Conclusion The blood lipid, glucose and UA in patients with EH cerebral hemorrhage are metabolism abnormal, the biomarkers of HCy and cTnⅠ could be used as valuable index in diagnosis of EH cerebral hemorrhage.