Objective To explore the serum level of Cystatin C (CysC) and its relationship with urinary albumin excretion (UAE) in patients with obesity related glomerulopathy. Methods 30 obesity patients with early obesity related glomerulopathy and 20 obesity patients without complication were enrolled in the study. 30 health check-up individuals were selected as control group. The levels of the serum CysC and UAE were measured by nephelometry and radioimmunoassay respectively. Results The levels of serum CysC in early obesity related glomerulopathy patients were significantly higher than those of the control group (P ＜0.01). There was a significant difference on serum CysC levels between early obesity related glomerulopathy group and simple obesity group. The serum level of Cys C was positively correlated with UAE in patients with early obesity related glomerulopathy. Conclusion The serum CysC levels can be a sensitive indicator to reflect the early stage damage in patients with early obesity related glomerulopathy.