Objectives To explore the influence of Shenyanqing Tablet on serum IL-6 and VEGF levels in patients with asymptomatic hematuria. Methods 76 cases of renal hematuria patients diagnosed by renal biopsy were randomly divided into treatment group and control group (n = 38 in each group). The serum levels of IL-6 and VEGF before and after treatment by Shenyanqing Tablet in patients with asymptomatic hematuria were detected. Results The serum levels of IL-6 and VEGF in treatment group were significantly lower than that of control group (P<0.05). Conclusion Shenyanqing Tablet could change the serum levels of IL-6 and VEGF in patients with asymptomatic hematuria, and it may have a certain effect on the improvement of hematuria symptom in the patients with asymptomatic hematuria.