Objective To explore the values of serum cystatin C (Cys-C), Urine Microalbuminand (UMAlb) and Urineβ2-Microglobin (β2-MG) in patients with liver cirrhosis. Methods The Serum Cys-C, umAlb (with immunoturbility assay) and Uβ2-MG (with ELISA) Levels were determined in 61 patients with liver cirrhosis (30 cases ascites the cirrhosis and 31 cases without ascites) and 35 healthy controls. Results The Serum Cys-C and UmAlb and β2-MG levels in patients were significantly higher than those in controls (P < 0.01). These markers in liver cirrhosis with ascites group were higher that that without ascites groups (P <0.01).The serum Cys-C levels were positively correlated with UmAlb and Uβ2-MG levels (r=0.6011，0.5984, P < 0.01). Conclusion The detection levels of serum Cys-C, UmALb and Uβ2-MG have important value in the early diagnosing renal function damage.