Objective To investigate the relationship between sex hormone, SHBG and T2DM, and the risk factors of T2DM in Uighur men. Methods 81 patients of T2DM and 65 normal controls were selected by randomly in study to detect blood pressure, the level of FPG, FINS, HbA1c, blood lipids, sex hormone and SHBG. HOMA-IR and BMI were calculated. All these indexes were compared between T2DM group and normal control group. Results The levels of FPG, FINS and HbA1c in T2DM group were higher than those of normal control group, and the levels of SHBG and T were lower than those of normal control group when the age, BMI, blood pressure, blood lipids were all matched between the two groups (P<0.05). Using Pearson correlation analysis and Spearman rank correlation analysis, in Uighur men patients with type 2 diabetes, SHBG and serum testosterone were negatively correlated with BMI (r =－0.485，r =－0.543), FINS (r =－0.467，r =－0.423), TG (r =－0.442，r =－0.351) respectively. Serum testosterone was positively correlated with HDL-c (r =0.317). Conclusion SHBG and serum testosterone may be the protective factors of T2DM in Uighur men.