rats of each group were beheaded after 6 hours focal cerebral ischemia-reperfusion. The levels of inflammatory cytokines tumor necrosis factor (TNF-α), interleukin 6 (IL-6) and interleukin 10 (IL-10) in beheaded brain of rats were detected. The brain infarction area and water content in brain tissue were also determined. Results The levels of inflammatory factor TNF-α and IL-6 in L-Arg treatment group rats were reduced and the expression of IL-10 was raised, the brain tissue water content and cerebral infarction area were also reduced. Conclusion L-Arginine play a role of anti-inflammatory by inhibiting the brain tissue inflammatory factor TNF and IL-6 and increasing the content of IL-10, which produces a degree of protection on cerebral ischemia in rats.