Objective To investigate the therapeutic effects of strontium-89 therapy in patients with bone metastases. Methods Seventy-five cancer patients with multiple bone metastases confirmed with whole body bone scan imaging were treated with strontium-89. The catabolic effects of bone pain, the changes of peripheral hemogram and bone metastases lesions were analyzed before and after strontium-89 therapy. Results Among seventy-five cases of patients, sixty cases appeared different degree of pain relief, and the remission rate was 80% (P＜0.01); Nineteen patients pain disappeared completely. There was no significant change for peripheral hemogram during treatment period and the bone metastases remission rate in all cancer patients was 89% (P＜0.01). Conclusion Strontium-89 therapy is an effective therapeutic method for patients with bone metastases with favorable effects on relieving pain, low reaction of toxicity and high remission rate.