Objective To analyze the clinical effect of CDFI-guided 125I seed implantation in the treatment of metastatic superficial tumor. Methods A retrospective analysis of 156 patients with metastatic superficial tumors treated with CDFI-guided 125I seed implantation was carried out. Three-dimensional computerized reconstruction and CT scanning with thin slice were used to make preoperative plan, operative adjustment and to verify the distribution and numbers of seeds after operation. The 125I seed were implanted under CDFI-guided after local infiltration anesthesia. Results Three month after operation, The tumors in 16.7％ of patients (26/156) were complete remission (CR), 51.3％ patients (80/156) were partial remission (PR), 21.1% patients (33/156) had no change (NC), 10.9％ patients (17/156) had progress disease (PD). The total effect rate was 68％ (CR+PR). Six month after operation, The tumors in 18.6％ of patients (29/156) were complete remission (CR), 53.2％ patients (83/156) were partial remission (PR), 22.4% patients (35/156) had no change (NC), 5.8％ patients (9/156) had progress disease (PD). The total effect rate was 71.8％ (CR+PR). There were no serious skin reactions, bone marrow suppression and other complications in all patients. Conclusion Brachytherapy with 125I seeds implantation guided with CDFI is a safe，minimally invasive and effective treatment method for metastatic superficial tumor.