Objective To investigate the relationships among serum lipoprotein (a) levels and apolipoprotein (a) gene SNP rs3798220 T/C polymorphism and coronary heart disease (CHD). Methods The CHD patients diagnosed by the coronary angiography were selected as CHD subjects (200 cases), and 200 healthy adults served as normal control subjects. The High Resolution Meiting (HRM) was performed to identity the distribution pattern of apolipoprotein (a) gene SNP rs3798220 in all subjects. The levels of serum lipoprotein (a) were measured. Results The frequency of T/C+C/C genotype and C allele in CHD patients were significantly higher than those in control subjects (P<0.05). Logistic regression analysis revealed that LPA SNP rs3798220 T/C+C/C genotype had a strong positive association with CHD (OR：2.878，95.0% CI：1.306~6.339，P<0.05). The serum lipoprotein (a) was positive associated with CHD (OR：1.068，95.0% CI：1.041~1.095，P<0.05). Conclusion The T/C+C/C genotype might be a possible risk factor for CHD and the serum lipoprotein (a) levels may have an association with the CHD .