Objective To investigate the clinical curative effects of 131I combined with lithium carbonate therapy for Graves disease (GD). Methods The clinical treatment materials of 5638 patients with GD patients were analyzed retrospectively．Results The cure rate of patients with GD after one single cycle of 131I therapy combined with lithium carbonate was 76.5%, and the improve rate was 19.8%. The total effective rate was 96.3% among the 5638 GD patients. The total effective rate was 93.8% among 178 GD patients with hyperthyroid cardiopathy. Among all GD patients, the patients with hypothyroidism was observed 569 (10.1％) after the first 131I therapy. Conclusion 131I combined with lithium carbonate therapy is an effective simple and safe method for the treatment of GD patients and GD patients with hyperthyroid cardiopathy. It may decrease the 131I treatment dose.