Abstract：Objective To explore the effects of Lornoxlcam on the serum of IL-2，IL-6 and IL-I0 in perioperative period of patients undergoing cholecystectomy and to study the mechanism of Lornoxicam on immunologic function. Methods forty patients scheduled for cholecystectomy operations were randomly allocated to either A or B group, each with 20 cases. The luminal and atropine was routinely used before operations. The patients in group A were intravenous dripped with 8mg of Lornoxicam before anesthesia, and then given Sufentanil to patient controlled intravenous anesthesia (PCIA). The patients in group B were intravenous dripped with 8mg of Lornoxicam at the end of the abdominal closure, and then given Sufentanil to the PCIA. The serum of interleukin-2 (IL-2)，Interleukin-6 (IL-6) and Interleukin-10 (IL-10) in all patients were measured at prior to anesthesia medication (T1), abdominal closure end immediately (T2), 6 hours after surgery (T3) and 24 hours after surgery (T4). Results There was no significant difference between the two groups in the levels of IL-2, IL-6 and IL-10 at T1 time point s(P＞0.05). The levels of IL-2 and IL-6 in group B were significantly higher than that of in group A at the T2, T3 and T4 time points (P＜0.05). The levels of IL-10 in group B were significantly lower than that in group A at the T2, T3 and T4 time points (P＜0.05). Conclusion Compare with the post-operation, the preoperative use of Lornoxicam could mitigate factors such as anesthesia, surgery on the inhibition of cellular immune function, and can effectively inhibit stress response in favor of postoperative recovery.