Abstract: Objective To explore the correlation of risk stratification of acute coronary syndrome（ACS）with ischemia modified albumin (IMA), heart fatty acid binding protein (H-FABP) and uric acid. Methods 70 patients were divided into unstable angina pectoris (UAP), ST-elevation myocardial infarction (STEMI) and non ST-elevation myocardial infarction (NSTEMI) group based on ACS standard. They were divided into low-risk, Intermediate-risk and high-risk groups based on GRACE risk score. Results 22 (31%) patients were admitted for UAP, 17 (24%) for NSTEMI, and 32 (45%) for STEMI. There were significantly difference in hospital mortality risk score and hospital mortality between UAP and NSTMEI groups (P＜0.05). The hospital mortality in STEMI group had significantly difference between low and high-risk group (P＜0.05). There were no significantly difference for serum H-FABP and UA levels in three groups (P>0.05). The serum IMA had clearly difference between low and high-risk group in NSTMEI (P＜0.01). Conclusion Hospital mortality risk score and hospital mortality play an important role in GRACE to indicate the disease severity. The serum H-FABP, IMA and UA levels cannot be considered as the indexes to judge the degree of ACS.