Objective To study the dynamic change of lipid metabolism in different thyroid function status during pregnancy. Methods This study recruited thirty cases of euthyroid, nineteen cases of subclinical hypothyroid and eight cases of subclinical hyperthyroid pregnancy. The concentrations of fasting serum total cholesterol（CHOL）and triglyceride（TRIG）were detected and analyzed at 9-12, 14-17, 23-26, and 37-40 gestational weeks. Results The statistical analysis showed that there were significant differences of maternal serum CHOL between subclinical hyperthyroid and euthyroid pregnancy, subclinical hyperthyroid and subclinical hypothyroid pregnancy (P<0.05). There was no significant difference between euthyroid and subclinical hypothyroid pregnancy (P >0.05). There was no significant difference of maternal serum TRIG among the three groups (P >0.05). Conclusion The concentrations of maternal CHOL and TRIG increased during pregnancy. The serum CHOL of subclinical hyperthyroid pregnancy was lower than that of euthyroid pregnancy. Concentrations of maternal serum CHOL was similar between euthyroid and subclinical hypothyroid pregnancy after treatment with drug. Different thyroid function status had no obvious effect on the metabolism of maternal TRIG.