Objective To compare the efficacy of 131I alone and 131I combined with prednisone tablets in the treatment of patients with Graves' disease（GD）and to predict the clinic value of the combined therapy. Methods 66 patients with GD received 131I therapy were divided into two groups：5mg prednisone tablets once a day starting 2 weeks after 131I therapy and continued for 6 weeks (group A ), 131I therapy alone (group B). The methimazole and bisoprolol tablets to alleviate symptom were given to patients in the both group when necessary were received s. The cure rate, cure time and methimazole and bisoprolol tablets consumption of two groups were compared. Results There was no significant difference on cure rate between group A and group B. However, the recovery time for thyroid function, methimazole and bisoprolol tablets consumption in group A were significantly less than that in group B ( P < 0.05). Conclusion 131I combined with prednisone tablets for the treatment of GD show potential efficacy, it may rapidly improve symptoms and reduce early complications.