Abstract：Objective To study clinical value of heart-type fatty acid-binding protein (H-FABP) in acute coronary syndrome (ACS). Methods The present study was carried out include acute myocardial infarction group (n=108, AMI), unstable angina group (n=90, UA), stable angina group (n=84, SA) and 60 people served as healthy control. The serum H-FABP, cardiac troponin I (cTnI) and creatine kinase MB fraction (CK-MB) levels were measured in all patients enrolled at admission and 8 hours after admission. Results At patients admission, the H-FABP level in AMI and UA groups were higher than that of in SA and controls (P<0.05), while the CK-MB level in AMI was higher than that of in other three groups (P<0.05). The H-FABP had significantly higher diagnostic accuracy superior to cTnI and CK-MB in AMI and UA (P<0.05). At 8 hours after admission, the H-FABP level trended to decline, while cTnI and CK-MK were increased. The H-FABP level in AMI was higher than that in other three groups (P<0.05). The levels of cTnI and CK-MB in AMI and UA were markedly higher than those in SA and controls (P<0.05). The H-FABP had no significant accuracy for AMI compared with cTnI and CK-MB (P>0.05), and less accuracy for UA than other two markers (P<0.05). The ACS with emergency had markedly higher H-FABP than that of without ACS (P<0.01). Conclusion H-FABP shows high accuracy for the early diagnosis in ACS patients, but other biochemical cardiac markers would be combined for diagnosis after 8 hours later from symptom onset. The H-FABP level could be used for prognosis evaluation of ACS.
LIU Hua-wei，YANG Qing，HE Chun-rong，MA Yu-hua，LI Jian-hong
. Clinical Value of Heart-type Fatty Acid-Binding Protein in Patients with Acute Coronary Syndrome[J]. Labeled Immunoassays and Clinical Medicine, 2013
, 20(6)
: 381
-384
.
DOI: 10.11748/bjmy.issn.1006-1703.2013.06.004
