Abstract: Objective To explore the value of serum ischemia modified albumin (IMA) in the early diagnosis of cerebral circulation disorder. Methods The patients with cerebral trauma (n=29), hypertensive vascular disease (n=37), cerebral infarction (n=41), arteriosclerotic cerebral vascular disease (n=36) and cerebritis (n=21) were involved in this study. The IMA levels of all patients were detected within 3 hours of onset and 6, 48, 72 hours. Results The serum levels of IMA in hypertensive vascular disease, cerebral infarction, arteriosclerotic cerebral vascular disease were significantly higher than those of healthy control (P<0.01), the IMA levels in cerebral trauma and cerebritis were also higher than that in healthy control (P<0.05), while the levels of IMA in hypertensive vascular disease, cerebral infarction and arteriosclerotic cerebral vascular were significantly higher than those in cerebral trauma and cerebritis (P<0.05). The optimal cutoff value of IMA was 120.32 U/ml in diagnosis of cerebral circulation disorder. At this point, its sensitivity and specificity were 90.22% and 70.21%. The levels of serum IMA at 3-72h in cerebral infarction would be upward trend. Conclusion IMA might be used as a biochemical index in early diagnosis of cerebral circulation disorder.
蹇国，贾萍
. Changes of Ischemia Modified Albumin in Cerebral Circulation Disorder Patients[J]. Labeled Immunoassays and Clinical Medicine, 2013
, 20(6)
: 374
-377
.
DOI: 10.11748/bjmy.issn.1006-1703.2013.06.002
