Objective To explore the relationship between plasma obestatin concentrations in abdominal obesity subjects and waist circumference (WC). Methods The present study comprised 2 groups, 50 Chinese abdominal obesity subjects (waist circumference of men ≥85cm，waist circumference of women ≥80cm), 20 age-matched normal subjects (waist circumference of men <85cm，waist circumference of women <80cm，BMI ≥24kg/m2）were included. The fasting plasma levels of obestatin and insulin were measured by RIA. Insulin resistance was calculated by the homeostasis model of assessment for insulin resistance (HOMA-IR) approach. Results Subjects with abdominal obesity displayed higher HOMA-IR, serum total cholesterol and triglyceride compared to normal control. The plasma obestatin concentrations in abdominal obesity group were lower compared to normal control. The plasma obestatin concentrations in abdominal obesity subjects were negatively related with WC and BMI. Conclusion The results in this study indicate that the obestatin might be important in distribution of body fat and development of abdominal obesity.
