Objective To explore the overall accuracy of plasma （1-3)-β-D-glucan assay for diagnosing of invasive fungal infections ((FI) with a meta-analysis. Methods The sensitivity，specificity，and positive and negative likelihood ratios of（1-3)-β-D-glucan in the diagnosis of IFI were pooled using a bivariate meta-analysis with ST AT A 11. Results Thirty- one studies were included for the analysis ( proven，probable，and possible IFI vs no IFI). The pooled sensitivity，specificity，PLR and NLR were0.79 (95% CI，0.73-0.85)，0.86 (95% CI，0.80-0.90)，5.64 (95% CI，3.818-8.352)，and 0.242 (95% CI，0.179-0.326)，respectively. Conclusion Plasma（1-3)-β-D-glucan assay is clinically useful for diagnosing IFI in at-risk patients.