Objective To investigate the technical points and the clinical effectiveness of transcatheter arterial chemoembolization (TACE) combined with CT-guided 125I seeds implantation for the treatment of liver cancer. Methods 75 cases of hepatic carcinoma were retrospectively collected and divided into group A (41 patients with TACE alone) and group B (35 patients with TACE combined with 125I seeds implantation sequential therapy).Efficacy evaluation was performed in 3 month，6 month and 1 year after the operation by CT scan，and the survival status of 6 month and 1 year were also recorded. Results The overall response (CR + PR) of group A and group B were 36. 6% ( 15/41 ) and 70. 6% (24/34 ) respectively at 3 months after operation with significant difference ( P = 0. 005 ) . The survival rate at 6 and 12 months in group B (97. 1% and 85. 3% ) were significantly higher than those in group A (73. 2% and 41. 5% ) (P <0.01). Conclusion TACE combined with CT- guided ¹²⁵I seeds implantation could be a safe and effective treatment for liver.