目的了解急性脑梗死患者血清胃泌素水平的变化及影响因素。方法应用RIA法测定95例急性脑梗死患者入院24h及1周时血清胃泌素水平，并与51名健康对照组比较。结果急性脑梗死组血清胃泌素水平明显升高，且胃泌素水平男女间无明显差异。继发胃肠症状组患者较无胃肠症状组患者胃泌素水平明显偏高，1周时无胃肠症状组胃泌素水平较入院24h有升高趋势。且脑干与脑叶梗死患者血清胃泌素水平升高显著。结论脑梗死组急性期血清胃泌素处于高水平，可基本排除单纯应激影响的结果，且胃泌素水平与梗死部位相关。此外脑梗死急性期并发的胃肠功能障碍与高胃泌素血症有一定的相关性。
Objective To observe the change and influence factors of serum gastrin (GAS)levels in patients with acute cerebral infarction. Methods The serum GAS levels of 24 hours and one week after admission in 95 patients with acute cerebral infarction and 51control subjects were measured by RIA. Results The GAS levels were significantly elevated after onset of patients with acute cerebral infarction, in which was no significant difference between male and female. The GAS levels of patients with gastrointestinal symptoms were higher than those without symptoms. The levels of GAS in patients without gastrointestinal symptoms within one week showed an increase tendency compared with the levels of 24 hours. The serum gastrin levels in patients with brainstem and lobar infarct were significantly increased。Conclusion The GAS Levels in patients with acute cerebral infarction keep at high levels, which can basically rule out the simple result of the impact stress. The level of GAS may be associated with the infarction region, and the acute cerebral infarction complicated with gastrointestinal dysfunction was related to the hypergastrinemia.
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