目的探讨五种血清肿瘤标志物（tumormarkers，TM）检测在肺癌诊断中的价值。方法采集73例肺癌患者、22例肺部良性疾病患者和25名正常人血清样本，采用免疫放射分析法检测神经元特异性烯醇化酶（NSE）和血清细胞角蛋白19片段（CYFRA211），酶免法检测癌胚抗原（CEA）、糖类抗原（CA125）和鳞状上皮相关抗原（SCC）。结果5种TM在肺癌组的浓度显著高于肺良性疾病组（P＜0.01），也显著高于正常人组（P＜0.01）。肺良性疾病组5种TM的浓度略高于正常人组，但差异无统计学意义（P＞0.05）。肺癌组血清NSE、CYFRA211、CEA、SCC和CA125的灵敏度分别为45.20%、41.09%、34.24%、53.42%、38.35%，特异性为80.85%、78.72%、80.85%、82.98%、74.47%。5种TM联合检测的灵敏度和特异性分别为93.15%和44.68%。结论血清NSE、CYFRA211、CEA、SCC和CA125联合检测对于肺癌的诊断有临床价值，合理的联合检测可以提高肺癌诊断的灵敏度，提高肺癌的检出率。
To explore the significance of five serum tumor markers(TM) detection in the diagnosis of lung cancer. Methods The serum levels of NSE, CYFRA 211, CEA, CA125 and SCC were detected with IRMA and ELISA in 73 patients with lung cancer, 22 patients with lung benign diseases and 25 healthy people. Results The serum levels of the five TMs in patients with lung cancer were significantly higher than that of in patients with lung benign diseases and healthy people（P＜0.01）. Although the five TMs levels in patients with lung benign diseases were slightly higher than that of healthy people, it was no statistical significance（P＞0.05）.The sensitivity of NSE, CYFRA 211, CEA, SCC and CA125 in patients with lung cancer were 45.20%，41.09%，34.24%，53.42%，38.35%，and the specificity of that were 80.85%，78.72%，80.85%，82.98%，74.47%.The sensitivity and specificity of five TMs combined detection were 93.15% and 44.68% respectively. Conclusion The combined detection of five TMs is useful in the diagnosis of lung cancer. The reasonable combined detection can improve the diagnostic sensitivity and the detection rate of lung cancer.
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