目的探讨血清肌红蛋白(Mb)在烧伤患者血清中的动态变化及其意义。方法将2012年5月至2013年4月于我院住院治疗的烧伤患者(烧伤面积>15%)61例设为观察组，并根据烧伤面积的不同进一步分为三组，分别对三组患者伤后第1、3、7天血清Mb、肌酸激酶(CK)、C-反应蛋白(CRP)、白细胞计数(WBC)及中性粒细胞百分比(NET%)进行检测，同法测定50名健康体检者血清相应指标作为对照组。同时动态观察烧伤患者病情变化情况，其中并发多器官功能障碍综合征(MODS)者9例。结果烧伤组伤后第1天与对照组比较，血清Mb、CK、CRP、WBC及NET%含量差异均有统计学意义(P＜0.05);随烧伤面积及采集时间的不同，血清中Mb、CK和CRP比较有显著差异(P＜0.05);烧伤并发MODS组血清Mb和CK水平显著高于非MODS组。结论Mb、CK和CRP的动态变化与烧伤患者病情严重程度、变化趋势及预后具有良好相关性，对MODS的早期诊断、治疗有重要意义，与其他炎性反应指标(CRP、WBC、NET%)联合监测对烧伤患者的救治具有较高临床价值。
Objective To investigate the dynamic changes of serum myoglobin(Mb) and its clinical significance in burn patients. Methods The serum levels of Mb, CK, CRP, WBC and percentage of NET in 61burn patients and 50 healthy controls were measured. The analyse-indexes of the vein blood collected from the burn patients were observedat 1, 3 and 7 days after burned, and 9 cases with MODS. Results The serum levels of Mb, CK, CRP, WBC and percentage of NET in 61burn patients were all distinctly different from healthy controls on the first day. The serum Mb, CK and WBC level of MODS group were obvious higher than that of non MODS group. Conclusion The serum Mb, CK and CRP can be regarded as valuable indexes in supervising burning patients state and may have significance in diagnosis and therapy of MODS.
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