目的探讨血清同型半胱氨酸(HCY)、尿素氮(BUN)、肌酐(Scr)、尿酸(Ua)和胱抑素(Cyc-C)在肾脏疾病中的变化及其诊断价值。方法检测193名正常对照者和136例肾脏疾病患者(包括肾炎、肾病综合征和肾功能不全患者)的血清HCY、BUN、Scr、Ua和Cys-C。结果在肾炎组和肾病综合征组中，HCY、Scr、Ua和Cys-C的含量高于对照组(P＜0.01);与肾炎组相比，肾病综合征组的HCY和Cys-C含量升高(P＜0.05)。与对照组相比，肾脏疾病组的HCY、BUN、Scr、Ua和Cys-C的阳性率均增加。HCY与BUN、Scr、Ua和Cys-C均有很好的相关性(P＜0.01)。结论肾脏疾病患者血清HCY、BUN、Scr、Ua和Cys-C含量明显升高，随病情的加重呈上升趋势，HCY与其他传统指标具有很好的相关性，对于肾脏疾病的辅助诊断具有重要意义。

Objective To evaluate the change and diagnosis value of HCY and related indicators in kidney disease. Methods The serum levels of HCY, BUN, Scr, Ua and Cys-C in 193 normal controls and 136 patients with kidney disease including nephritis patients, nephrotic syndrome patients and renal insufficiency patients were tested. Results The serum levels of HCY, Scr, Ua and Cys-C in patients with nephritis and nephrotic syndrome were higher than those in normal control (P＜0.01). Compared with the nephritis group, the serum HCY and Cys-C in nephrotic syndrome group were increased (P＜0.05). The positive rate of kidney disease group were higher than the control group. The serum HCY had good linear correlation with BUN, Scr, Ua and Cys-C. Conclusion The serum levels of HCY, BUN, Scr, Ua and Cys-C in kidney disease patients are increased. The serum HCY levels are linear correlated with other traditional indicators. The serum HCY may have important significance for the auxiliary diagnosis of kidney disease.