目的了解腹膜透析能否改变终末期肾病患者细胞免疫功能。方法采用流式细胞仪检测CD3+、CD4+、CD4+/CD8+比值和NK细胞。结果与腹膜透析前相比，腹膜透析后6个月、12个月，CD3+、CD4+、CD4+/CD8+比值均升高，CD3+透析后12个月与6个月相比继续升高。CD8+腹膜透析后无变化。NK细胞腹膜透析后6个月、12个月分别与透析前相比，均有明显下降。结论腹膜透析可以改善终末期肾病患者的细胞免疫功能。
孙建洁
,
陈超
,
石峰
,
丁俊丽
,
王丽
,
姚素花
,
马立萍
,
银广悦
. 腹膜透析对终末期肾病患者NK细胞和T细胞亚群的影响[J]. 标记免疫分析与临床, 2013
, 20(2)
: 76
-78
.
DOI: 10.11748/bjmy.issn.1006
bjective To detect whether peritoneal dialysis can change the cellular immune function in patients with endstage renal disease.Methods The expression of CD3+, CD4+ and the rate of CD4+ / CD8+ were determined by the flow cytometric method. Results Compared with the patients before peritoneal dialysis, the expression of CD3+, CD4+ and the rate of CD4+ / CD8+ were significantly increased in the patients with peritoneal dialysis after 6 months, 12 months respectively and more higher than that of in the patients after 12 months. CD8+ had no significantly changes after peritoneal dialysis. NK cells were significantly decreased in the patients with peritoneal dialysis after 6 months, 12 months respectively. Conclusion The peritoneal dialysis can improve cellular immune function in ESRD patients.
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