目的探讨¹³¹I治疗Graves病(GD)早发甲减可定量的影响因素。方法对经¹³¹I治疗的GD患者的甲状腺质量和摄碘率、患病年龄、性别、病程、ATD治疗等因素与早发甲减进行统计分析。结果男、女间¹³¹I首次治疗或第二次治疗的治愈率、早发甲减率差异无统计学意义(P＞0.05);¹³¹I治疗的甲状腺质量低于30g的早发甲减率显著高于31g的GD患者(P＜0.05);24h摄碘率45%～95%间早发甲减率差异无统计学意义(P＞0.05);年龄在21～65岁的早发甲减率虽差异无统计学意义(P＞0.05)，但早发甲减率与年龄呈∪型走势;16～20岁患者比21～65岁的患者，其甲状腺更易受辐射损伤(P＜0.05);GD病程大于6月与5～10年间早发甲减率有随病程延长而升高的趋势，但差异无统计学意义(P＞0.05);ATD治疗后的早发甲减率比治疗前差异有统计学意义(P＜0.01)。结论¹³¹I治疗GD中:甲状腺质量小于30g和年龄小于20岁的患者早发甲减率以及ATD治疗后的早发甲减率，差异有统计学意义(P＜0.05);患病性别、病程、甲状腺摄碘率等可定量的影响因素与早发甲减率，差异无统计学意义(P＞0.05)。

Objective To explore the quantitative influence factors of early hypothyroidism(EH) in ¹³¹I treatment of patients with graves disease (GD). Methods The thyroid mass, iodine uptake rates, age, gender, illness course and anti-thyroid drugs (ATD) in GDs patients with ¹³¹I treatment were recorded and used for the analysis of influence factor of early hypothyroidism. Results In all ¹³¹I treated GDs patients, there were no statistically significant difference on cure rates and incidence of EH (P＞ 0.05), no matter male or female, the first ¹³¹I treatment or second treatment. The EH rate of the ¹³¹I treated GDs patients with their thyroid mass less 30g was significantly higher than that of >31g(P＜0.05 ). There was no significant difference on EH rates for patients with 24h thyroid iodine uptake between 45%～95%(P＞0.05), the patients between the age of 21to 65 years(P＞0.05). The relationship between the EH rate and the age appeared to be ∪ type trend, and the thyroid was more susceptible to radiation damage over the age of 20 (P＜0.05). The EH rate of the patients with GD duration more than 6 months, and between 510 years showed increasing tendency with the extension of the course, but the difference between them was not statistically significant(P＞0.05). The EH rate for patients before and after ATD treatment had a significant difference ( P＜0.01). Conclusion The thyroid mass, age and ATD may be the main influence factors to induce the early hypothyroidism in the ¹³¹I treatment patients with GD.