摘要： 目的 探讨慢乙肝中度患者的甲状腺指标（TSH、FT3、TT3、FT4、TT4）水平变化及其相互关系。方法 收集在本院2014年下半年住院的慢乙肝中度患者34例、慢乙肝轻度患者30例及30例正常体检者，检测血清的TSH、FT3、TT3、FT4、TT4，并进行统计分析。结果 (1)3组间的甲状腺指标相互比较，差异有统计学意义（P<0.05）。(2)组间两两比较，FT3和FT4差异有统计学意义（P<0.05）。(3)TSH与FT3呈直线负相关（r=-0.370，P=0.031），与TT4呈直线正相关（r=4.735，P=0.000）。FT3与TT3呈直线正相关（r=0.613，P=0.000）。FT4与TT4呈直线正相关（r=0.499，P=0.003）。结论 甲状腺激素指标在评价慢乙肝中度患者的肝功能损害有重要的临床意义。

Abstract：Objective To explore the changes of thyroid hormone index level of TSH, FT3, TT3, FT4 and TT4 and their relations in moderate chronic hepatitis B patients. Methods The serum levels of TSH, FT3, TT3, FT4 and TT4 in 34 cases of moderate chronic hepatitis B patients, 30 cases of mild chronic hepatitis B patients and 30 normal controls were detected and the results were analyzed. Results There was significantly difference on thyroid hormone index among three groups (P < 0.05). The serum levels of FT3 and FT4 had statistically difference between any two groups (P< 0.05).（3）The serum TSH levels in chronic hepatitis B patients was negatively correlated with FT3 (r = 0.370, P = 0.031), and positively correlated with TT4 (r = 4.735, P = 0.000). The FT3 and TT3 showed linear positive correlation (r = 0.613, P = 0.000), and FT4 and TT4 showed linear positive correlation (r = 0.499, P = 0.003). Conclusion The thyroid hormone indexes could have very important clinical significance in the evaluation of chronic hepatitis B patients with moderate liver function damage.