摘要： β2-糖蛋白-I (beta2-glycoprotein I, β2-GPI) 在体内与氧化低密度脂蛋白、氧化脂蛋白(a)结合形成复合物，在伴有高动脉粥样硬化风险的自身免疫性疾病及心脑血管疾病等患者血清中水平显著升高，且与体内高氧化应激状态和炎症反应相关，是预测动脉粥样硬化发生、发展的新的危险因素。本文就近年来有关β2-GPI与氧化脂蛋白复合物的检测和临床意义研究作一综述。

Abstract: Beta2-glycoprotein I (β2-GPI) combined with oxidized low density lipoprotein or lipoprotein (a) in vivo could generate the β2-GPI/ox-LDL or β2-GPI/ox-Lp(a) complexes respectively. Patients with autoimmune diseases at high risk of atherosclerosis or cardio-/cerebrovascular diseases exhibited the increased levels of β2-GPI/ox-LDL and β2-GPI/ox-Lp(a) in their serum. The complexes also showed the close associations with enhanced oxidative stress and inflammation in vivo. These data indicate that β2-GPI/ox-LDL and β2-GPI/ox-Lp(a) may be the novel risk indictors to predict the pathogenesis and progression of atherosclerosis. This review summarized the studies related to the detection methods and clinical significance of β2-GPI complexes with oxidized lipoproteins.