摘要：目的  探讨2型糖尿病合并冠心病患者血清游离脂肪酸和超敏CRP含量的变化。方法   对103例2型糖尿病合并冠心病患者、105例2型糖尿病不合并冠心病患者及51名健康对照者，采用酶法测血清游离脂肪酸，免疫比浊法测超敏CRP，比较检测结果，并对2型糖尿病合并冠心病的危险因素行Logistic回归分析。结果  2型糖尿病合并冠心病患者组与2型糖尿病不合并冠心病患者组和正常对照组比较，游离脂肪酸和超敏CRP都显著增高（P ＜0.01）。以2型糖尿病组为整体，有无合并冠心病为因变量Y（有=1，无=0），以年龄、体质量指数、吸烟例数、血压、血糖、血脂、游离脂肪酸和超敏CRP等为自变量，进行Logistic回归分析，最后游离脂肪酸和超敏CRP进入回归方程。结论  游离脂肪酸、超敏CRP是2型糖尿病患者合并冠心病的重要危险因素。

Abstract: Objective To investigate the changes of serum levels of free fatty acids and high-sensitivity C-reactive protein in patients with type 2 diabetic mellitus and coronary heart disease. Methods 103 cases of type 2 diabetic mellitus with coronary heart disease, 105 cases of type 2 diabetic mellitus without coronary heart diseases and 51 health controls were selected into this study. The levels of serum free fatty acids were measured with enzymatic colorimetric method and high-sensitivity C-reactive protein were measured with immunoturbidimetry. Serum free fatty acids and high-sensitivity C-reactive protein and other factors related to type 2 diabetic mellitus and coronary heart disease were analyzed with multiple stepwise logistic regressive analysis. Results The serum levels of free fatty acids and high-sensitivity C-reactive protein in type 2 diabetic mellitus with coronary heart disease were significantly higher group than those in the type 2 diabetic mellitus without coronary heart disease and normal controls (P<0.01). The serum free fatty acids and high-sensitivity C-reactive protein were related significantly with type 2 diabetic mellitus with coronary heart disease. Conclusion The serum free fatty acids and high-sensitivity C-reactive protein are important risk factors of type 2 diabetic mellitus with coronary heart disease.