摘要：目的 探讨P选择素( P- selectin)、高敏C 反应白蛋白( hs- CRP)、血小板在冠心病及急性心肌梗死患者血清中的变化及临床意义。方法 选取急性心肌梗死患者40例,冠心病患者40例, 健康对照者40例。采用酶联免疫吸附试验( EL ISA )方法, 测定血清中的P选择素、hs- CRP 、血小板水平, 运用q检验等统计学方法进行分析。结果 急性心梗患者P选择素显著高于冠心病组和对照组, 冠心病组高于对照组，差异具有统计学意义。急性心梗患者hs- CRP明显高于冠心病组和对照组,冠心病组与对照组差异无统计学意义，血小板三组之间差异无统计学意义。结论 P选择素的变化是血小板活化较特异的指标, 对缺血性心脏病的判定有重要价值，优于hs- CRP，联合检测hs- CRP更能反映冠心病的发展趋势。

Abstract: Objective To investigate the changes and clinical significance of serum P-selectin level, high sensitivity C reactive protein (hs-CRP) and platelet in patients with coronary heart disease (CHD) and acute myocardial infarction (AMI). Methods 40 cases of AMI, 40 cases o f CHD and 40 cases of normal people were involved in this study. The levels of serum P-selectin, Hs-CRP and platelet were analyzed by ELISA. Results The levels of P-selectin in patients with AMI were higher than those CHD and normal controls. The levels of P-selectin in patients with CHD were higher than normal controls. The levels of hs-CRP in patients with AMI were higher than those CHD and normal controls. The levels of hs-CRP in patients with CHD and normal people had no significant difference. The levels of platelet in patients with AMI and CHD and normal people had no significant difference. Conclusion The P-selectin is the marker of platelet activation and may play an important role in prediction of AMI and CHD.