摘 要：目的 了解眼部感染患者病原菌分布及耐药情况，为临床药物合理使用提供依据。方法 采用Kirby-Bauer(K-B)法进行药敏试验，数据分析采用WHONET 5.6软件。结果  占眼部感染比例前两位的病原菌分别是凝固酶阴性葡萄球菌(CNS)和大肠埃希菌。前者对左旋氧氟沙星和庆大霉素的耐药率（24.2%和18.9%）远低于β-内酰胺类和大环内酯类；后者对大部分抗菌药物具有较低的耐药率，其中包括阿米卡星和环丙沙星（0%和27.3%）。结论 眼部感染前两位病原菌分别是CNS和大肠埃希菌，两者都对喹诺酮类药物和氨基糖苷类药物有较低的耐药率，可以做为治疗眼部感染的首选药物。

Abstract: Objective To determine the distribution and drug resistance of pathogen in patients with ophthalmic infection, and to provide evidences for the clinical usage of antibacterial agents. Methods Drug sensitive were studied by Kirby-Bauer methods, and the date of MIC were analyzed by WHONET5.6. Results Coagulate-negative staphylococci (CNS) accounted for the most of all the pathogen identified from infectious patients, followed by Escherichia coli. The resistance rate of CNS to levofloxacin and gentamycin were lower than that of β-lactams and Macrolides. The resistance rate of Escherichia coli to the most antimicrobial agents was low, including amikacin and ciprofloxacin. Conclusion The primary pathogens of patients with ophthalmic infection are CNS and Escherichia coli. Both organism display low drug resistance rate to quinolones and aminoglycoside, and can be used as the drug of choice for the treatment of ophthalmic infection.