摘要：目的  探讨胰岛素样生长因子1（insulin-like growth factor-1,IGF-1）、胰岛素样生长因子结合蛋白-3（insulin-like growth factor binding protein-3,IGFBP-3）、CEA及CA125联合检测对肺癌诊断的临床价值。方法  采用化学发光法分别对77例肺癌患者和41名健康体检者血清IGF-1、IGFBP-3、CEA和CA125水平进行检测,并对检测结果进行对比分析。  结果  肺癌组血清IGF-1水平明显高于健康对照组（P<0.01），血清IGFBP-3水平明显低于健康对照组（P<0.05）；单项检测时IGF-1灵敏性为28.57%，CEA灵敏性为44.16%，CA125灵敏性为40.26%；三项指标联合检测时灵敏性为75.33%。 结论  IGF-1有助于肺癌的诊断，IGF-1、CEA及CA125联合检测可显著提高肺癌检出率。

Abstract: Objective To investigate the clinical significance of combined detection of insulin-like growth factor-1(IGF-1), Insulin-like growth factor blinding protein-3 (IGFBP-3), CEA and CA125 in the diagnosis of lung cancer. Methods The serum levels of IGF-1, IGFBP-3, CEA and CA125 in 77 patients with lung cancer and 41 healthy subjects were measured by chemiluminescence immunoassay and nephelometry. Results The serum levels of IGF-1 in patients with lung cancer were significantly higher than those in healthy subjects (P＜0.01). The serum levels of IGFBP-3 in patients with lung cancer were lower than those in healthy subjects (P＜0.05). The sensitivity in single detection of IGF-1, CEA and CA125 was 28.57%, 44.16% and 40.26%. The sensitivity in combined detection of IGF-1, CEA and CA125 was 75.33%. Conclusion IGF-1 contributes to early diagnosis of lung cancer and the combined detection of IGF-1, CEA and CA125 could significantly improve the detection rate of lung cancer.